Endocrine Abstracts

Abstract unavailable....

Bone loss in anorexia nervosa and following bariatric surgery is associated with an elevated circulating concentration of the gastrointestinal anorexigenic hormone peptide YY (PYY), which acts principally via the Y1R and Y2R receptors. Selective deletion of Y1R in osteoblasts or Y2R in the hypothalamus results in high bone mass, but deletion of PYY has resulted in conflicting skeletal phenotypes leading to uncertainty regarding its role in the regulation of bone mass. We hypot...

Background: The gut hormone PYY3-36 (PYY) is released into the circulation after eating and physiologically inhibits food intake. Obese and lean subjects are equally sensitive to this effect, however fasting levels of PYY are reduced in obese subjects.Methods: We investigated the postprandial PYY response and satiety response using a visual analogue scale (VAS) to 6 test meals of increasing calorie content in 20 lean and 20 obese subjects. We also infuse...